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Listar por autor "Morales, Juan C."
Mostrando ítems 1-15 de 15
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Antioxidant activity of alkyl gallates and glycosyl alkyl gallates in fish oil in water emulsions: Relevance of their surface active properties and of the type of emulsifier
González, M. Jesús; Medina, Isabel; Maldonado, Olivia S.; Lucas Rodríguez, Ricardo; Morales, Juan C. (Elsevier, 2015)The antioxidant activity of gallic acid and a series of alkyl gallates (C4-C18) and glycosylated alkyl gallates (C4-C18) ...
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Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites
Falomir, Eva; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Martí Centelles, Rosa; Dupont, Alexia; Zafra-Gómez, Alberto; Carda, Miguel; Morales, Juan C. (Wiley-Blackwell, 2016)Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability ...
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Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
López Martín, Sergio; Montserrat de la Paz, Sergio; Lucas Rodríguez, Ricardo; Bermúdez Pulgarín, Beatriz; Abia González, María del Rocío; Morales, Juan C.; García Muriana, Francisco José (Elsevier, 2017)The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative ...
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Effects of Sugar Functional Groups, Hydrophobicity, and Fluorination on Carbohydrate–DNA Stacking Interactions in Water
Lucas Rodríguez, Ricardo; Peñalver, Pablo; Gomez Pinto, Irene; Vengut Climent, Empar; Matashobya, L.; Cousin, J.; Sanchez Maldonado, Olivia; Reynes, Virginie; Aviñó, Anna; Eritja Casadellà, Ramón; González, Carlos; Linclau, Bruno; Morales, Juan C. (American Chemical Society, 2014)Carbohydrate–aromatic interactions are highly relevant for many biological processes. Nevertheless, experimental data in ...
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Experimental Measurement of Carbohydrate–Aromatic Stacking in Water by Using a Dangling-Ended DNA Model System
Morales, Juan C.; Reina, José J.; Díaz Contreras, Irene; Aviñó, Anna; Nieto, Pedro M.; Eritja Casadellà, Ramón (Wiley-VCH, 2008)Protein–carbohydrate recognition is of fundamental importance for a large number of biological processes; carbohydrate–aromatic ...
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Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity
Reyes Darias, J. A.; Sánchez Luque, Francisco J.; Morales, Juan C.; Pérez Rentero, Sonia; Eritja Casadellà, Ramón; Berzal Herranz, Alfredo (John Wiley & Sons, 2015)Antisense oligodeoxynucleotides (ODNs) are short synthetic DNA polymers complementary to a target RNA sequence. They are ...
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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA
Vengut Climent, Empar; Gómez Pinto, Irene; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Aviñó, Anna; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan C. (Wiley-Blackwell, 2016)Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA ...
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Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions
Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Reina, Jose J.; Eritja, Ramón; González, Carlos; Morales, Juan C. (American Chemical Society, 2011)Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these ...
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Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells
Atzeri, Angela; Lucas Rodríguez, Ricardo; Incani, Alessandra; Peñalver, Pablo; Zafra-Gómez, Alberto; Melis, M. Paola; Pizzala, Roberto; Morales, Juan C.; Deiana, Monica (Royal Society of Chemistry, 2016)The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) ...
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Metabolites and tissue distribution of resveratrol in the pig
Azorín-Ortuño, María; Yáñez-Gascón, María J.; Vallejo, Fernando; Pallarés, Francisco J.; Larrosa, Mar; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco A.; García-Conesa, María T.; Espín, Juan C. (Wiley-Blackwell, 2011-08)Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism ...
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Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents
Larrosa, Mar; Tomé-Carneiro, Joao; Yáñez-Gascón, María J.; Alcántara, David; Selma, María V.; Beltrán, David; García-Conesa, María T.; Urbán, Cristina; Lucas Rodríguez, Ricardo; Tomás-Barberán, Francisco; Morales, Juan C.; Espín, Juan Carlos (American Chemical Society, 2010-10-28)There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring ...
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Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines
Selma, María V.; Larrosa, Mar; Beltrán, David; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco; Espín, Juan C. (American Chemical Society, 2012)The efficacy of resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives in inhibiting the adhesion of ...
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Surface-Active Properties of Lipophilic AntioxidantsTyrosol and Hydroxytyrosol Fatty Acid Esters: A PotentialExplanation for the Nonlinear Hypothesis of the AntioxidantActivity in Oil-in-Water Emulsions
Lucas Rodríguez, Ricardo; Comelles, Francisco; Alcántara, David; Maldonado, Olivia S.; Curcuroze, Melanie; Parra, Jose L.; Morales, Juan C. (American Chemical Society, 2001)Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters ...
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The Gut Microbiota Ellagic Acid-Derived Metabolite Urolithin A and Its Sulfate Conjugate Are Substrates for the Drug Efflux Transporter Breast Cancer Resistance Protein (ABCG2/BCRP)
González Sarrías, Antonio; Miguel, Verónica; Merino, Gracia; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás Barberán, Francisco; Álvarez, Ana I.; Espín, Juan C. (American Chemical Society, 2013)The breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter that can affect the pharmacological and ...
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Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
García Muriana, Francisco José; Montserrat de la Paz, Sergio; Lucas Rodríguez, Ricardo; Bermúdez Pulgarín, Beatriz; Jaramillo Carmona, Sara; Morales, Juan C.; Abia González, María del Rocío; López Martín, Sergio (Royal Society of Chemistry, 2017)Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass ...